This study examined indirect associations of MyTeachingPartner coaching with pre-K students' (N = 1,570; 73% low income) school readiness, via improvements of teachers' (N = 393; 47% Black; 41% Head Start) classroom interactions. Data were collected across 2008-2009 and 2009-2010 in 10 urban sites across the eastern United States. The number of completed coaching cycles was examined as a predictor of teacher-student interactions, as were direct or indirect associations with students' literacy, receptive language, and working memory skills. Significant findings indicated that teachers engaged in more feedback cycles showed greater improvements in instructional interactions, in turn predicting greater increases in students' early literacy and working memory. Results confirm the theory of change for coaching and an ecological-developmental conceptualization of school readiness.