Educational kits can improve the teaching of experimental sciences, providing an interesting strategy to be explored at home, especially during the COVID-19 pandemic. In this sense, chemistry kits based on a microscale design were developed encompassing safety, portability, efficacy, and low cost. They were successfully applied in regular classes and distance learning courses at the University of São Paulo. This article provides the basic guidelines and is complemented with details and examples in the Supporting Information. The kits are adaptable to all levels of teaching, from elementary school to the university. Their application aims to enhance the student skills and interest in science.