This study aims at checking the effects of an early intervention program (EIP) on the neuropsychomotor development (NPMD) and quality of life (QoL) of 4-18 months old babies attending daycare, following the biopsychosocial (BPS) model of health and the International Classification of Functioning Disability and Health (ICF). It was a quasi-experimental cross-over study, with the evaluations (NPMD and QoL) and interventions (locomotor, stabilizer and manipulative in a circuit format) of 66 babies carried out in the daycare, following an EIP, twice a week, during 4 weeks. The EIP for favoured motor behaviours acquisition, demonstrating that the percentage of babies with risk/delay decreased just after the EIP and positive effects were identified in Physical Capacity in QoL. It is concluded that the proposed EIP program for 4--18 months old infants in daycare showed positive effects on NPMD and QoL, including domains of ICF of function, activity and participation.