The present study aimed to investigate Orphan and Vulnerable Children (OVC) care needs and determine the related driving forces and challenges. The current study adhered to a qualitative emergent design to obtain insight into the attitudes of all individuals engaged in providing care services for OVC. In addition, the challenges and driving forces concerning satisfying OVC care needs were investigated employing the focus group method. Based on the findings, a majority of the care needs of OVC included physical health, psychological, educational, social working, and finally, physical/anatomical needs. Overall, the present study mainly aimed to uncover the essential care needs of OVC, along with the challenges and driving forces regarding usual OVC caregiving in Iran. Managers should pave the way for desirably meeting OVC care needs through attracting further financial and spiritual support, as well as the cooperation of the contributing organizations and key partners and qualified human sources.