Rejection Sensitivity (RS) is defined as the disposition to anxiously expect, readily perceive, and overreact to social rejection cues. Aim of the two studies presented in this paper was to develop and administer an instrument to assess RS in a German sample of healthy (pre)adolescents as well as in a clinical sample. The English Children's Rejection Sensitivity Questionnaire (CRSQ) was translated, adapted, and presented to a non-clinical sample (N?=?128) (Study I) to identify psychometric properties of the instrument. In Study II, the resulting questionnaire was completed by a mixed clinical sample (N?=?50). Differences in results between samples, and the relation between rejection sensitivity and mental distress were investigated. The resulting German version of the questionnaire CRSQ (German: "Fragebogen zur Zurückweisungsempfindlichkeit für Kinder und Jugendliche, FZE-K") showed good psychometric properties. Differences between samples provide insight into the diversity of the construct "rejection sensitivity".