The interplay between sense of entitlement and hope might have a unique contribution to mothers of children with developmental disabilities (DD) life satisfaction. Seventy-three mothers of children with DD and 47 mothers of children without DD participated in the study. Mothers of children with DD (vs. without DD) experienced low levels of life satisfaction and high levels of entitlement. The relationship between being a mother of children with DD and life satisfaction was mediated by the interaction between sense of entitlement and hope. Higher entitlement was "negatively" related to life satisfaction when mothers' hope was low and "positively" related to life satisfaction when mothers' hope was high. Entitlement can act as a resource for life satisfaction, depending on hope levels.