Background: Unhealthy weight control and disordered eating behaviors are prevalent among adolescents who identify as a gender and/or sexual minority (SGM). The current study examined how perceptions of school safety contribute to reduced negative weight control and eating behaviors across adolescents with diverse sexual and gender identities. Methods: Data on perceptions of school safety, as well as negative weight control and disordered eating behaviors (i.e., binge eating, eating to cope), were drawn from a large national sample of SGM secondary school students (i.e., grades 7-12; N = 17,112; "LGBTQ National Teen Survey"). Results: Differences in negative weight control and disordered eating behaviors emerged as a function of gender identity and sexual orientation. School safety was significantly associated with fewer negative weight control behaviors (B = -0.30, p < 0.001), reduced binge eating (B = -0.19, p < 0.001), and less eating to cope (B = -0.21, p < 0.001). Despite slight variation in the strength of these associations, the protective effects of school safety were significant across sexual and gender identities. Conclusions: Findings suggest that efforts to support feelings of school safety among SGM students are likely to have positive implications for eating and weight-related behaviors, and emphasize the need for interventions to promote climates of safety and inclusion within the school setting.