Comprehensively improving the quality of education in resource-poor areas is an urgent challenge to achieve balanced development of basic education in China. In the process of educational development in resource-lacking areas, information technology has: (1) changed the traditional teaching mode and teaching environment, (2) provided high-quality educational resources, (3) promoted the professional development of teachers, and (4) promoted the overall improvement of education quality. Southwestern Guizhou Prefecture in Guizhou Province, China, has become a typical case in using information technology to promote education quality improvement in areas with scarce educational resources. This article explores educational information technology in the region as an example to discuss how to grasp the regional characteristics and local needs in the layout of information technology, integrate information technology into teaching practice, and steadily improve the overall teaching quality of the region.