The authors look back on their participation in three successful multiyear research studies focused on multifaceted vocabulary instruction and distill four overarching lessons that provide practical guidance to schools and teachers interested in implementing effective comprehensive vocabulary instruction. Specifically, they elaborate on the value of instruction that addresses quality, quantity, and strategy dimensions of vocabulary learning; teaching many types of high-value words; employing versatile instructional strategies such as using visual images and creating vocabulary collections; and seizing opportunities to foster students' word consciousness. The authors also describe and illustrate a number of practical activities that teachers can employ to enhance their students' word learning.