Developing students' self-study capacity is an urgent task of high schools in the current educational renovation period in Vietnam. This article presents research findings on developing self-study capacity for students through building and organizing teaching activities of 11th-grade organic chemistry project topics according to the blended learning model. The pedagogical experiment was conducted at three high schools in the north, central, and south regions of Vietnam with 125 students. The data obtained from the teacher's assessment and the students' self-assessment showed obvious development of students' self-study capacity in experimental classes.