This study aimed to examine the prevalence and predictors of depression and anxiety among senior high school students in Jordan during the COVID-19 pandemic. The study used an anonymous online survey that targeted senior high school students in Jordan. Almost two thirds of students reported depressive symptoms and anxiety. Father's level of education, mothers' level of education, perceived difficulties in online education, gender, and age were significant predictors of depression, while father's level of education, difficulties in online education, gender, and age were significant predictors of anxiety (p < 0.05). Among those identified as having depression, 30.7% were male and 50.7% were female. The prevalence of anxiety among students was high, and the prevalence of anxiety in females (46.9%) is greater than males (27.6%). School health nurses and mental health counselors at schools need to emphasize the mental health and psychosocial support needs for senior high school students.