COVID-19 has changed about every aspect of life including how we teach in higher education. Laboratory experiments vital for learning hands-on techniques are limited due to social distancing requirements and increased numbers of distance-learning students. The solution to loss of hands-on activities has been to compensate with virtual laboratory modules. Although virtual labs are engaging and offer a simulated hands-on approach to teaching essential molecular techniques, these simulations do not replace hands-on experience. I designed two molecular biology laboratory exercises in response to the current teaching limitations that can be completed 'at-home' and enable low cost hands-on instruction of essential molecular techniques in any distance-learning environment including during the COVID-19 pandemic.