This study, it was aimed to determine the motivation of students to learn science according to learning styles and the effect of differentiated teaching practices on their opinions. A mixed research design consisting of a preliminary pre test-post test model with a control group and a qualitative data combination was used. The survey was conducted on 4th-grade students. 63 students, 30 in the experimental group and 33 in the control group, constituted the study group. The data were collected using the "Motivation Scale for Science Learning" and the "semi-structured interview form." As a result of non-working findings, it is concluded that differentiated teaching practices according to learning styles are more effective for students' motivation towards science learning than traditional teaching methods and that teaching-oriented student views support differentiated teaching practices.