The aim of this study is to reveal the relationship between academicians' career barriers and academic alienation. General screening model which is used in the research work of the working group in Turkey are 203 state universities academics. In the study, 19-item Career Barrier Scale was used to determine the career barriers of academics, and the Academic Alienation Scale with 21 items was used to determine the level of academic alienation. According to the results of the research, there is a positive relationship between career barriers and isolation. In addition, isolation is explained by career barriers to a great extent.