Science denial has a long history of causing harm in contemporary society when ignored. Recent discussions of science denial suggest that correcting people's false beliefs rarely has an impact on eliminating the adherence to false beliefs and assumptions, which is called the backfire effect. This paper brings the backfire effect within the context of science denial to the attention of science education researchers and practitioners and discusses the potential role(s) of epistemic understanding of knowledge production in science in dealing with the rejection of scientific evidence and claims in science classrooms. The use of epistemic understanding of knowledge production in science with a focus on avoiding the backfire effect may increase the potential for science education research to produce fruitful strategies which advance students' attitudes toward science and deepen students' understanding of how science works through divergent perspectives. There are some areas that need to be focused on and investigated for their potential to combat science denial and the backfire effect while foregrounding the role(s) epistemic understanding of knowledge production for science instruction. These areas include expanding ways of knowing and marking the boundary between the scientific way of knowing and other ways of knowing at the same time, comparing claims and arguments that derive from different frameworks, teaching about the power and limitations of science, and bringing different and similar ways science is done to students' attention.