Some students with gifts and talents (SWGT) are among the thousands of youths who die by suicide every year, although there is no way to know how many. Research indicates they are not more likely to engage in suicidal behaviors than other students. They do have unique risk and protective factors, however. Risk factors can accumulate to outweigh protective factors, causing a downward trajectory toward psychache, a condition of intense psychological pain and hopelessness. Without intervention, SWGT suffering from psychache are in imminent danger of suicide. This paper outlines an ecological model of suicidal behavior among SWGT that provides an explanation and framework for future research and prevention efforts.