Objective: To evaluate the measurement structure of the "Job Satisfaction of Persons with Disabilities Scale" (JSPDS) in a sample of employed U.S. Americans with disabilities. Design: A quantitative descriptive design using exploratory factor analysis (EFA) and correlational analysis. Participants: Two hundred and fifty-nine individuals with disabilities who were employed at least 10 hours per week. Results: The EFA indicated a two-factor structure accounting for 42.99% of the total variance. The internal consistency reliability coefficients for the "Integrated Work Environment and Job Quality" factors were 0.87 and 0.74 respectively. Both factors correlated with selected employment and well-being variables in logical directions. Conclusion: The two-factor measurement structure of the JSPDS appears to be valid and interpretable, and can be used in research and clinical settings in order to develop effective strategies for long-term employment success of people with disabilities