This paper proposes the production of animated comics in POWTOON to serve as a visual collaborative tool and a teaching-learning strategy for a course on Operations Research. This proposal aims to achieve meaningful learning of the subject matter, incentivizing the creativity of undergraduate students of marketing and business at the Guadalajara University, given that the production of comics develops, in students, cognitive and practical abilities such as the following: reflection; critical thinking; observation; analysis; synthesis; analogy; systematization; a sense of collaboration; and, teamwork. To validate the substantial improvement in student performance after producing the comic, a paired two-sample means t-test was carried out for 35 undergraduate students of marketing and business at the Guadalajara University who were enrolled in the same Operations Research course. The results obtained show that student performance improved considerably after the production of the comics, facilitating both teaching and the students' significant learning. In this sense, the use of POWTOON demonstrated to be a good learning alternative, since the students for the realization of the comic were able to recover and review the information acquired, write a script, and organize images, videos, sounds, and text in a congruent and didactic way, even when it comes to complex topics.