This study assessed quality assurance practices in Colleges of Education in Akwa Ibom and Cross River States, Nigeria. Three null hypotheses were formulated to guide the study. The survey research design was adopted for the study. The population of the study comprised ninety (90) Heads of Departments and Deans of Schools in the three Colleges of Education under study. Census sampling was used to select the sample size of 90 Heads of Department and Deans of Schools. To test the three hypotheses, data was generated using an 18-item questionnaire titled "Assessment of Quality Assurance Practices Questionnaire" (AQAPQ). The instrument was validated by experts in Educational Administration and Planning, and Measurement and Evaluation. The reliability of the instrument was established using Cronbach Alpha reliability method with the results ranging from 0.76 to 0.85. Population t-test analysis of single mean was used for data analysis. The results of the analysis revealed that quality assurance variables such as maintenance of infrastructure and students' admission policy were significantly low, while curriculum implementation was not significantly low in Colleges of Education in Akwa Ibom and the Cross River States. It was concluded that quality assurance practices in Colleges of Education in Akwa Ibom and the Cross River States, Nigeria were high in curriculum implementation, while in the maintenance of infrastructure and students admission policy, it was low. Based on the findings, it was recommended among others that, administrators of Colleges of Education should endeavour to ensure that quality assurances are effectively practiced to achieve the desired results.