Nowadays, owning to the failure of the Traditional Educational System, the only option left is the Virtual Educational, which will change the educational system at 180 degrees. The aim of this study was to investigate and evaluate the relationship between different factors associated with the level of satisfaction amongst students of Medical Science University during the pandemic outbreak of COVID-19. This cross-sectional study was performed among students of Birjand University of Medical Sciences in 2020. They completed the questionnaire was created using a Google platform and their answers was collected online. Satisfaction towards virtual educational learning plus total evaluation scores for various dimension of questionnaire was analyzed. A total of 320 out of 2700 students participated in the study voluntarily. Students' satisfaction with blended method in teaching style was higher and significant than two separate styles (p<0.05), but there was no significant relationship between satisfaction level and some demographic characteristics. Also, the majority of participants (41.7%) have a medium level of Satisfaction. There was significant relationship between the amount of computer skills, Semester and sex with overall satisfaction (p<0.05). Students demonstrated a moderate satisfaction and positive attitude towards VR educational system which comprises of a "Virtual Learning Room" at home for both the teacher and student. To be able to implement education in medical universities in the coronavirus crisis, electronic and internet infrastructures need to be completed quickly, and officials should take steps to empower students and teachers to take advantage of this opportunity.