This article describes four key principles from Targeted Reading Instruction (TRI, formerly called Targeted Reading Intervention), an evidence-based early reading intervention and professional development program. Focused on accelerating the growth of students not yet meeting grade-level expectations, one-on-one 15-minute daily TRI lessons engage students in developing phonemic awareness, phonics knowledge, decoding, fluency, vocabulary, and beginning reading comprehension. Four key principles guide TRI, which can be applied to classroom reading instruction. First, all work is done in the context of real words and connected text, placing "meaning at the heart" of instruction. Second, lessons "keep it moving," as they follow a consistent structure, use activities to achieve multiple objectives, and make use of all available resources. Third, TRI teachers "let the student do the work," engaging students in productive struggle. Fourth, "explicit teaching of skills" such as blending provides students with unique strategies to become confident independent readers.