Marginalized youth face many barriers in the development of career aspirations, despite the fact that career development training is a crucial part of school curricula and ethical mandates. This article provides a conceptual framework for the role of culturally responsive small-group work in promoting the development of career goals among students, especially marginalized youth. Small-group work serves as an effective approach for the facilitation of social well-being, social connectedness, and self-motivation as important aspects of career development. The authors conclude with key recommendations for improving the effectiveness of research on culturally responsive small-group work in schools.