The human relation to things in the world is at stake in the so-called post-humanist era where the distinction between human and non-human is blurred, as indicated in a term like 'the nano-self'. How should we understand the nature of our relation to things in this era? Or how can we describe an "educationally" meaningful relation we as human agents can make in relation to things, artificial and natural, in the face of this technologically hybrid and ever-dehumanizing tendency of society? Well-known for his actor-network theory, Bruno Latour, an influential materialist and philosopher of technology, says that 'objects' have agency as much as humans; so we need to be able to "translate" the language of things into the language of men or vice versa as a way of co-shaping the world we live in. What does this mean and how can we do so? In carefully examining his theory, the essay attempts to explore and reformulate his account of the mediating role of human agency to see if it can provide us with an educationally plausible post-humanist concept of human agency, which can lead us into an ecologically ethical and politically responsible approach to education in general, and science education in particular.