A comprehensive school physical activity program (CSPAP) is a multi-component approach that aims to provide opportunities for students to meet the nationally recommended 60 minutes of moderate-to-vigorous physical activity (MVPA) per day and for students to be well-equipped to be active for life. In order for a CSPAP to be effectively implemented, it should be led by a trained physical activity leader (PAL). This review summarizes recent literature related to the roles and responsibilities of a PAL, various outlets in which aspiring PALs can be trained, and the potential effectiveness of PAL-led CSPAPs.