Higher education institutions are increasingly adopting leaning management systems (LMS) as a complementary tool in improving learning systems. The purpose of this study is explore the factors influencing students' satisfaction in Palestine Technical University-Khadoury (PTUK) in Palestine toward using the learning management system (Moodle). Six potential factors were used including perceived ease of use, perceived usefulness, information quality, system quality, service quality, and computer self-efficacy. Surveying strategy was used to collect the required data; 372 questionnaires were analyzed using simple and multiple regression. The findings revealed that all the examined predictors had significant influence on students' satisfaction toward using LMS. These findings enrich the previous literature with input towards adopting learning management systems in higher education institutions. The authors recommended that the LMS at PTUK should be integrated with social media platforms, and designed in a way that allow it to work fully and properly on mobile phones.