There is a need for strong multitiered systems of support (MTSS) in rural schools, given that students living in rural areas experience poverty and transience and rural schools serve as the primary resource for addressing child academic, social, emotional, and behavioral problems. MTSS is important for preventing negative student outcomes, promoting student success, and proactively reducing the proportion of students who need special education services. In addition, across a number of states, including Florida, MTSS implementation is an eligibility requirement for certain special education programs (e.g., specific learning disability). MTSS implementation in rural schools is often challenging due to limited access to high-quality evidence-based interventions and a lack of structure and consistency in procedure. There is a need for strong multitiered systems of support (MTSS) in rural schools, given that students living in rural areas experience poverty and transience and rural schools serve as the primary resource for addressing child academic, social, emotional, and behavioral problems. MTSS is important for preventing negative student outcomes, promoting student success, and proactively reducing the proportion of students who need special education services. In addition, across a number of states, including Florida, MTSS implementation is an eligibility requirement for certain special education programs (e.g., specific learning disability). MTSS implementation in rural schools is often challenging due to limited access to high-quality evidence-based interventions and a lack of structure and consistency in procedures, professional development opportunities, interventionists, and time to implement interventions. The authors who are school l psychologists responsible for service delivery across an entire rural school district (a total of 14 schools, 10,149 students, and 30 support staff, including counselors, mental health professionals, behavior specialists, social workers) in North Florida, they set out on a daring 2-year venture as MTSS systems-level change leaders. They determined there was a significant need for systems-level change given numerous problems with MTSS implementation, including a lack of (1) data-based decision making (e.g., reliance on teacher referral and anecdotal evidence, insufficient data, one-size-fits-all interventions, broad-based instead of targeted interventions); (2) collaborative problem-solving efforts (e.g., lack of specified teams, individuals making decisions in isolation); and (3) consistent and efficient policies and practices (e.g., limited training and guidance, misinformation and misconceptions about MTSS, lack of administrator support). In addition they set out to promote best practice implementation of MTSS across the district, empower school staff to engage in collaborative problem-solving and data-based decision making, and create consistent and efficient procedures for implementation. The ultimate goal was to create a stronger MTSS service delivery system and lead systems-level change across the district in order to reduce high inappropriate referral rates for special education and improve MTSS implementation to proactively address the academic, social, emotional, and behavioral functioning of all students.