As the COVID-19 pandemic posed a great deal of challenge to the higher education community, the curricula for online instruction had to be developed in a very short time period. Adaptations for Organic Chemistry I and II with Laboratory courses have been made for the online transition in response to the pandemic, and the insights gained through individual and collaborative efforts are presented by Georgia Gwinnett College (GGC) Organic Chemistry faculty. Herein, course specific information with a distinction between lecture and lab and the analysis of student assessment and withdrawal provide insights into the virtual instruction. The initiative of instructors played a crucial role during the transition and for maintaining student engagement, and the insights will add valuable resources for further virtual or hybrid instruction.