Scaffolded inverse blended learning (SIBL) enables self-paced, individualized learning by incorporating different levels of learning activities. The SIBL approach is described for an online general chemistry course enhanced with face-to-face interactions for first-year students in an institute of higher learning. It can be easily modified and implemented in situations where learning is disrupted (i.e., COVID-19 pandemic). Due to the COVID-19 pandemic, all schools and institutes of higher learning are required to transit into home-based learning. It could also be adapted by other courses. Students' feedback and performance indicate that the SIBL approach increases engagement in learning and develops students' ability to solve higher level problems.