Schools serve an essential function for individuals with autism spectrum disorder (ASD) and complex needs. However, school-based instruction may be interrupted due to pandemics, natural disasters, and school shootings, and as a result, schools are forced to stop traditional services and begin teaching students in their homes. Fortunately, distance education strategies are available to mitigate brick and mortar interruptions. When rural schools close, they face unique challenges, such as proximity to students, and technology limitations. In this article, we describe strategies for teachers to develop instructional materials, communication supports, and behavioral supports. We also describe how caregivers might provide support, and how to teach caregivers the skills necessary for effective support implementation.