We examine the role of the Big Five personality traits in the job exploration process of Latino undergraduate business students to ascertain the personality traits and socio-cognitive variables that lead to greater success of students in their job searches. We find that personalities such as extraversion and conscientiousness are positively associated with career self-efficacy, career expectations, and interests in both academic and professional skills, which in turn positively influence job exploration behaviors. Additionally, we find that personalities such as agreeableness and neuroticism have a negative influence on career exploration behaviors. Our findings provide Latino business students with college vocational guidance that can help enhance their career confidence, job beliefs, and career interests in the job-seeking process.