Combinations of text and different types of pictures are commonplace in biology as in science in general. The single representations (i.e., text, picture) constituting a text-picture combination may contain redundant or complementary information. The ability to identify and integrate information in different kinds of text-picture combinations is indispensable for engaging in science and is normatively expected to be acquired in school. In this experimental study, which was not preregistered in an independent institutional registry, N = 240 undergraduate students worked on 2 constructed-response biology tasks originating from authentic final exams to obtain the higher education entrance qualification. The material carried equivalent information between conditions but consisted of redundant or non-redundant text-picture combinations or only texts. Analysis of variance revealed negative effects of the depictive representations on students' performance, but these effects only occurred in 1 of the 2 tasks: Students in the text-only group reached the highest mean score, those who worked with the non-redundant text-picture combinations the lowest mean score. Implications for science education are discussed.