Systems-level consultation and implementation science research has resulted in increased understanding of how to facilitate large-scale use of evidence-based practices. This article aims to build upon what has been learned to-date by calling for consultation researchers to focus more on the human interactions within change processes. The rationale for increased focus on how consultants, consultees, and clients make sense of and experience systems change processes is provided. Additionally, a vision for a research agenda is shared, including potential research questions, design and analysis considerations, and potential outcomes of engaging in this line of research.