This study examined the effects of integrating instructional materials in Facebook on students' awareness and practice of laboratory safety. A quasi-experimental pretest-posttest two-group design was used in the study. The results indicate: 1.) The exposure to (Online Social Networking-Based Health Education) OSNBHE can improve students' awareness of laboratory safety (ALS) (p < 0.05); 2.) The exposure to OSNBHE can improve practice of laboratory safety (PLS) (p < 0.05); and, 3.) The ALS does not predict PLS (R[superscript 2] = 0.09, CI = 95%).