The selection of a previous framework or model as a basis for measuring the degree of teachers' knowledge in teaching has been carried out by some studies in different places to improve teacher preparation programs and, thus, to improve educational outcomes. This descriptive study aimed at exploring the degree of EFL teaching knowledge for Saudi teachers in Madinah city, according to the TPACK framework. Hundred and ninety-one male and female EFL schoolteachers participated in the study. A questionnaire was hired to collect the data. The findings of the study showed that the degree of teaching knowledge for Saudi EFL teachers in Madinah city, in general, was high, according to the TPACK framework. The results also indicated a significant difference among EFL teachers in the degree of teaching knowledge attributable to their gender in favor of female teachers, and to their stage in favor of secondary stage. Finally, the study presented many recommendations based on its results to elevate EFL teachers' knowledge in teaching.