Examined in this study is the question of whether students in STEM courses perform better and have more positive perceptions than students in non-STEM courses, when both are offered in the blended format. As part of a blended learning initiative, 6 STEM and 8 non-STEM university courses were redesigned using the blended format. Students (n=318) were surveyed on perceptions of their blended experience and courses grades were compared. Results indicated that STEM students performed significantly higher than non-STEM students; however, STEM students did not perceive their courses as positively as non-STEM students. The conclusion was that focusing blended learning course redesign in STEM fields in higher education may be advantageous, although more research is needed to confirm the findings and to investigate why student perceptions were relatively low for STEM students.