Gifted youth frequently experience perfectionism, which for some can affect their emotional well-being. This study evaluated the effectiveness of a 6-week mindfulness intervention for 42 middle school students who were identified as Gifted and Talented. Participants' levels of self-oriented and socially prescribed perfectionism, as well as their use of mindfulness practices, were evaluated pre- and post- intervention, as well as at a 5-week follow-up to assess changes in perfectionism ratings and use of mindfulness. Three Bonferroni-adjusted, one-way, repeated measures analyses of variance were performed, and the results indicated a significant decrease in self-oriented perfectionism and an increase in mindfulness at both the end of the intervention and at follow-up. These findings support the use of mindfulness as an appropriate intervention to reduce self-imposed forms of perfectionism among gifted youth.