This study was carried out to investigate knowledge, attitude and practical response of adult population to global campaign on climate change in Lagos State, Nigeria arising from the observation that climate change or global warming as the greatest threat facing the human race. This study adopted the descriptive survey research of the Ex-post Facto Type. The population of this study comprised all the adults resident in Lagos state with specific reference to the following: Market women association (Epe division), Radio transport workers union Epe division), Academic staff unions in tertiary institutions (Michael Otedola College of Primary Education EPE Lagos), Non-Academic staff unions in tertiary institutions (Michael Otedola College of Primary Education EPE Lagos), and Secondary school teachers (international Secondary School, (Michael Otedola College of Primary Education EPE Lagos), The sample size of 600 respondents was selected through proportionate and simple random sampling techniques. The findings showed that significant proportion of the respondents of the study had a low knowledge of what climate change is as well as its causes and effects on human existence. So also, the attitudinal disposition of majority of the respondents to climate change was indifference. The findings equally showed that both the formal and informal communication channels should be used for advocacy and public awareness of climate change particularly on how to make responsible decisions and choices towards ensuring a safer environment and healthy planet. Finally, findings revealed that the most appropriate area of focus for public enlightenment is to educate people to consume less electricity, to drive cars which burn less oil or gasoline, to buy local and organic foods/farm produce close to their areas of production, to buy local and organic foods/farm produce close to their areas of production, to buy energy-efficient electronics and appliances with energy star label.