This protocol presents the plan for a systematic review that investigates the effect of oral language interventions for children with intellectual disability (ID), language disorder (LD), autism spectrum disorder (ASD), Down syndrome (DS), Williams syndrome (WS), and fragile X syndrome (FXS). Language development is a highly frequent area of difficulty for children within these diagnostic groups, and oral language interventions are therefore important. However, to provide better evidence-informed practice, what oral language interventions are effective and for whom needs to be investigated. The systematic review not only investigates the effect of oral language interventions targeted at specific disorders but also identifies interventions that may yield similar improvements in different neurodevelopmental disorders.