Information that is different from scientific knowledge, consistent and resistant to change, can be expressed as misconceptions. Misconceptions are one of the critical factors that prevent students from understanding in Biology education. This study was conducted in Kosovo with high school 12th-grade students of three different ethnic origins. It is aimed to determine the misconceptions that students have about "Digestive System in Human" comparatively. The study was carried out with 150 12th grade students in Kosovo in the 2016/2017 academic year. The research was carried out with qualitative research techniques as a data collection tool consisting of student drawings and explanations, and true/false items used. A descriptive analysis made. The findings showed that the students had many misconceptions about the human digestive system. Some Turkish students have drawn the digestive system with the kidney and intestine compared to other ethnic groups. Albanian and Bosnian students generally draw the digestive system after the stomach for separate solids for liquids. This misconception may be related to the concept of image (prima de perception) (Bachelard, 1938). Also, cultural misconceptions stemming from language encountered. Bosnian students use the concept of "boiling" instead of "digestion".