How language is used has political implications as well as communicational consequences. Regional development, using means of systematic support for innovation, is a widespread phenomenon globally that also includes numerous political ambitions and implications. This article argues that ambiguities regarding the use of terms such as 'innovation system' and 'innovation support system' need to be clarified to improve communication in this field, as well as to reveal underlying political ideas on how systematic support for innovation should be carried out, by drawing on examples from studies of regional systems. Such ambiguities contribute significantly to the often-mentioned lack of involvement and engagement in regional development on the part of higher education institutions and academics. Examining key terms and concepts of this discourse, in the interests of promoting a common and stringent use of terminology, helps to illuminate whether the desired academic involvement in innovation processes relates to ideation, implementation and commercialization, or to support for processes through the contribution of knowledge and expertise.