Homophobic name-calling is commonplace in middle schools and is emerging as an antecedent to more serious, deleterious concerns, including depressive or anxious symptoms among youth. While music education researchers suggest that youth enrolled in music ensembles are targets for homophobic epitaphs, little is known about how experiencing homophobic teasing during early adolescence relates to their self-reported mental health. Using data from a large-scale investigation of middle school youth, we examined the prevalence of homophobic name-calling and its relationship on indicators of mental health, including depression and anxiety. Results indicate that being a target of homophobic victimization has significant mental health consequences for youth in the current sample, although differentially for youth participating in a music ensemble and those who do not. Music ensembles are complex social environments, and our results raise questions about how prevalent or localized homophobic epitaphs are for youth enrolled in music ensembles when compared with those who are not.