The aim of this study is to highlight the importance of teaching interventions in accordance with Bronfenbrener's Ecosystem Theory. The research questions address, how reading skills are taught in the microsystem of school through a Targeted, Individual, Structured, Integrated Program for Students with Special Educational Needs (TISIPfSENs) and how meso- exo-, macro- and chrono-system shape the structure of the intervention to enhancing reading skills. The methodology refers to a case study of a student with intellectual disability (ID) in Greece. The results indicate that the student with ID has enhanced his reading skills. The conclusions highlight the factors that influence and shape the educational intervention of reading skills in students with ID in accordance with Bronfenbrener's Ecosystem Theory.