The BIOSEL (Biotechnology Series Learning) model is a learning model that provides opportunities for students to assemble learning through a conceptual description of the coherent and precise steps of Biotechnology implementation. The purpose of this research was to analyze validity and practicality of the BIOSEL model to improve the concept mastery and scientific creativity of junior high school students. This research was conducted in the Odd Semester of the 2018/2019 Academic Year at Ex Residency of Besuki Junior High Schools (Jember, Banyuwangi, Bondowoso, and Situbondo) which involved 140 junior high school students of class XI through purposive sampling. The validity instruments used were validation sheets for learning and material content experts and for user. Meanwhile, the practicality instrument used was an observation sheet focusing on learning implementation, relevant student activities, and obstacles found during learning. The results of BIOSEL model validity showed that the model had the content, construct, and face validities that had fulfilled the feasibility to apply in the learning process. In addition, the results of BIOSEL model practicality included implementation of each syntax with an average value of < 3.6 as a very good category, student activities with an average value of < 85% as a very active category, and the obstacles found that had the appropriate alternative solutions.