The present study focuses on the association between peer integration and the development of depressive symptoms in secondary school students. A sample of 393 7th grade students (194 boys, 199 girls, mean age = 13.38 years, sd = 0.85) was recruited from 25 secondary schools in Austria. Of these students, 34 were diagnosed as having special educational needs. The screening version of the depression questionnaire DTK-II and the subscales "social relationships" and "perceived appreciation by the teacher" from the FEESS 3-4 were used for assessment. Structural equation modeling shows that negative teacher-student relationships predict both poor peer integration and depressive symptoms. Teacher-student relationships in schools have an impact on the peer integration as well as on the mental health of students.