Introduction: This investigation evaluates whether an intervention involving mindfulness-based practices, socio-affective activities, and socio-cognitive instances can foster prosocial attitudes and positive social relationships and reduce perceived stress in children. Method: The study was conducted with 44 children (20 girls and 24 boys) aged between 6 and 8 (M= 7.25 years, SD= 0.43), and followed a quasi experimental wait list design with two measurement time points (pre and post intervention). We analyzed relative changes in social integration, universal altruism and perceived stress levels. Results: Our results revealed that children who participated in the intervention showed an enhancement in social integration and universal altruism tests, and a decrease in the perceived stress indices. That is, children chose more peers as playmates and rejected fewer of them, while evidencing more prosocial attitudes. Discussion and Conclusion: Our findings suggest that this kind of intervention can contribute to fostering social integration and prosociality while promoting children's health and wellbeing from an early age.