Special education teachers (SETs) are expected to use effective practices to improve outcomes for students with disabilities, yet even those who are well-prepared may not be effective in teaching these students, as problematic working conditions may limit their opportunities to teach effectively and their longevity in the profession. To complicate matters, the context of SETs' work has changed, calling into question the nature of their roles in supporting student learning. The purpose of this article is to provide a broad overview of what is known about working conditions and to articulate how we might improve them. The authors identify key themes from the research literature about the relationship of SETs' working conditions to their early experiences in schools and their burnout, attrition, and effectiveness. The authors then outline an action agenda focused on researching and leveraging the roles of varied stakeholders, teacher educators, educational leaders, and professional organizations to improve these conditions.