An e-mentoring program was established to support females who were studying or intending to study or work in Science, Technology, Engineering or Maths related disciplines (STEM) and were located in regional, rural or remote areas. Mentors and mentees were matched based on their shared interests, fields of study and area of employment. The mentoring program aimed to support mentees' career development and smoother transitions from study into the workforce by providing an opportunity to develop knowledge and networks necessary to achieve their career goals. Data were collected through pre and post online surveys and semi-structured interviews. This paper describes the experiences of e-mentoring for participants located in rural and remote locations and shares implications for implementation of e-mentoring and suggestions for improvement for future e-mentoring projects.