The 3D visualization program paves the way for the development of virtual reality. This study produces a 3D visualization program in virtual reality to increase high school students' critical thinking skills and scientific attitude. The Research and Development (R&D) method was based on the ADDIE model - analysis, design, develop, implement, and evaluate with quasi experimental -- posttest design. The data of students' scientific attitude was collected through questionnaire adapted from several books and jounals, and those of the students' critical thinking skills was collected through chemical bonding test. A total of 96 grade 10th students were cluster randomly selected from senior high school in Gunungkidul Regency, Yogyakarta, Indonesia. The samples were set into three different classes, namely Class CG using a wet laboratory, Class EG-1 using a virtual reality laboratory integrated hybrid learning, and Class EG-2 using both of them. Based on the MANOVA test, it was found that students who used 3D visualization had better results in critical thinking skills and scientific attitudes.