The U.S. university-based extension system model has been successful nationally, but not adopted globally. Various historical factors rendered the U.S. system a less attractive option for emerging post-WWII nations. However, current changes in education and extension landscapes are creating new opportunities for the globalization of U.S. Extension. Specifically, both the U.S. and Chinese extension systems now face the common challenge of delivering meaningful university-based extension under shifting conditions. This commonality creates opportunities for exploring long-term, synergistic university-based extension systems and potentially achieving associated benefits worldwide.