In this article, the authors describe an innovative charades-based educational game, HeadsUp! Econ, and its use for effective economics instruction. Results of a self-assessment survey of students demonstrate that implementing HeadsUp! Econ as an active learning game provides students opportunities to: (1) practice identifying which concepts are important, (2) practice recalling and understanding those concepts), (3) learn a new way to approach studying rooted in effective learning evidence, (4) compare their learning progress and preparation with their peers, and (5) engage with economics in a shared, fun and positive way. The authors provide suggested best practices and sample materials for instructor use of HeadsUp! Econ, and a review of recommendations for best-practices in using educational games.